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In vitro, Gleevec inhibits the cytochrome P450 isoenzyme CYP2D6 activity at similar concentrations that affect CYP3A4 activity.

No other anticancer agents were allowed during treatment, and no dose modifications were allowed for hematologic toxicity during the first 14 days of therapy.

The active vasculitis associated with rheumatoid disease occurs in about 1 of this patient population.

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It is now recommended that Gleevec be administered as adjuvant therapy for 36 months after complete gross resection of GIST for adult patients with KIT (CD117)-positive GIST.

Adjuvant" studies are being conducted on hundreds of GIST patients whose tumors were resected, with the goal being to determine whether or not Gleevec can retard tumor recurrence.

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WEDNESDAY, April 18, 2018 HealthDay News Toxic chemicals that have been banned for nearly four decades may be hiding in kitchens across the United States, new research suggests.

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