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The Flexner report resulted in accreditation standards that closed half of American medical schools.
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In vitro, Gleevec inhibits the cytochrome P450 isoenzyme CYP2D6 activity at similar concentrations that affect CYP3A4 activity.
No other anticancer agents were allowed during treatment, and no dose modifications were allowed for hematologic toxicity during the first 14 days of therapy.
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Use in children under the age of 18 is infrequent; consultation with a specialist (such as a pediatric oncologist) is recommended.
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It is now recommended that Gleevec be administered as adjuvant therapy for 36 months after complete gross resection of GIST for adult patients with KIT (CD117)-positive GIST.
Adjuvant" studies are being conducted on hundreds of GIST patients whose tumors were resected, with the goal being to determine whether or not Gleevec can retard tumor recurrence.
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Gleevec can have good results, so it may be worth the cost.
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